Option C contains a run-on sentence (I would call it a comma splice).
A better way to phrase the sentence could be:
A giant clam grows huge; it can weigh hundreds of pounds.
A giant clam grows huge. It can weigh hundreds of pounds.
The answer is C. A giant clam grows huge, it can weigh hundreds of pounds.
The run-on sentence in the given options is option C: 'A giant clam grows huge, it can weigh hundreds of pounds.' This sentence incorrectly connects two independent clauses with a comma. It can be corrected by using a semicolon or by splitting it into two separate sentences.
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